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A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of sedative/ hypnotics. Some of these changes may be characterized by decreased inhibition (eg, aggressiveness and extroversion that seemed out of character), similar to effects produced by alcohol and other CNS depressants. Other reported behavioral changes have included bizarre behavior, agitation, hallucinations, and depersonalization. Amnesia and other neuropsychiatric symptoms may occur unpredictably. In primarily depressed patients, worsening of depression, including suicidal thinking, has been reported in association with the use of sedative/hypnotics.
Ambien, like other
sedative/hypnotic drugs, has CNS-depressant effects. Due to the rapid onset of
action, Ambien should only be ingested immediately prior to going to bed.
Patients should be cautioned against engaging in hazardous occupations
requiring complete mental alertness or motor coordination such as operating
machinery or driving a motor vehicle after ingesting the drug, including
potential impairment of the performance of such activities that may occur the
day following ingestion of Ambien. Ambien showed additive effects when combined
with alcohol and should not be taken with alcohol. Patients should also be
cautioned about possible combined effects with other CNS-depressant drugs.
Dosage adjustments may be necessary when Ambien is administered with such
agents because of the potentially additive effects.
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